Based at the University of Maryland School of Medicine, the Pasetti lab is a multi-functional group within the Center for Vaccine Development (CVD). In addition to a thriving basic research program, the Pasetti lab includes an Applied Immunology Section, which performs a variety of immunological assays under a quality program to measure immune responses to vaccines during human clinical studies. The Pasetti lab develops, refines, standardizes, and validates immunological methods for the purpose of assessing immune responses during infection and vaccination.
What we do
The Pasetti lab researches vaccines and immunology to understand how protective immunity can be induced in animal models and in humans following infection and vaccination, and the mechanisms involved. We investigate novel vaccine strategies, antigen delivery systems, adjuvants, and immunization regimens for protection against pathogens that affect young children, as well as the influence of maternal immunity on infant immune responses to vaccines, and the impact of vaccine combination on long-term health and protection.
The lab's primary areas of interests are pediatric vaccines, neonatal and infant immunology, and maternal immunization. We are particularly interested in vaccines that include live attenuated Salmonella and Shigella (alone or encoding foreign antigens), protein subunit vaccines, and polysaccharide conjugates. We are working on a new concept for a broadly protective pediatric vaccine against Salmonella, Shigella, and Yersinia based on conserved Type III secretion proteins, evaluating immunogenicity and protective efficacy in adult, neonatal, and maternal-infant animal models.
If you are interested in learning more about the Pasetti lab, please feel free to contact us by email.